Loci affecting gamma-glutamyl transferase in adults and adolescents show age 3 SNP interaction and cardiometabolic disease associations
نویسندگان
چکیده
Rita P. Middelberg1, Beben Benyamin1, Marleen H.M. de Moor2, Nicole M. Warrington3, Scott Gordon1, Anjali K. Henders1, Sarah E. Medland1, Dale R. Nyholt1, Eco J.C. de Geus2, Jouke J. Hottenga2, Gonneke Willemsen2, Lawrence J. Beilin4, Trevor A. Mori4, Margaret J. Wright1, Andrew C. Heath5, Pamela A.F. Madden5, Dorret I. Boomsma2, Craig E. Pennell3, Grant W. Montgomery1, Nicholas G. Martin1 and John B. Whitfield1,∗
منابع مشابه
Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations.
Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers. We have discovered novel loci affecting GGT in a genome-wide association study (rs1497406 in an intergenic region of chromosome 1, P = 3.9 × 10(-8); rs944002 in C14orf73 on chromosome 14, P ...
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